Hypersensitivity: Serious hypersensitivity reactions (eg, anaphylaxis, angioedema) have been reported in patients treated with Ozempic ®.Monitor renal function when initiating or escalating doses of Ozempic ® in patients reporting severe adverse gastrointestinal reactions. A majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration. Some of these events have been reported in patients without known underlying renal disease. Acute Kidney Injury: There have been postmarketing reports of acute kidney injury and worsening of chronic renal failure, which may sometimes require hemodialysis, in patients treated with GLP-1 receptor agonists.Inform patients using these concomitant medications of the risk of hypoglycemia and educate them on the signs and symptoms of hypoglycemia. Hypoglycemia: Patients receiving Ozempic ® in combination with an insulin secretagogue (eg, sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia.Pen-sharing poses a risk for transmission of blood-borne pathogens. Never Share an Ozempic ® Pen Between Patients: Ozempic ® pens must never be shared between patients, even if the needle is changed.Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy. The effect of long-term glycemic control with semaglutide on diabetic retinopathy complications has not been studied. Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy. The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline than among patients without a known history of diabetic retinopathy.
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If pancreatitis is suspected, discontinue Ozempic ® promptly, and if pancreatitis is confirmed, do not restart. Observe patients carefully for signs and symptoms of pancreatitis (persistent severe abdominal pain, sometimes radiating to the back with or without vomiting). Pancreatitis: Acute and chronic pancreatitis have been reported in clinical studies.Risk of Thyroid C-Cell Tumors: Patients should be referred to an endocrinologist for further evaluation if serum calcitonin is measured and found to be elevated or thyroid nodules are noted on physical examination or neck imaging.
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